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In tolerance assay, at 42 h after the end of conditioning regimen, shorter preconvulsive latencies than in healthy (non-diazepam conditioned) mice following isoniazid (800 mg/kg i.p.) (as hallmark of tolerance) were observed if diazepam (5.0 mg/kg i.p.) was again given acutely to mice previously conditioned with diazepam alone (use of picrotoxin 3.0 mg/kg i.p., as convulsant, with acute application of diazepam in previously diazepam conditioned mice did not lead to tolerance hallmark)

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In its natural context, this protein appears to play a role in the stomach's remarkable ability to: Maintain mucosal integrity despite constant acid exposure Rapidly repair minor daily damage to the stomach lining Protect against ulcer formation Coordinate healing responses after injury The synthetic BPC-157 peptide is more stable than the natural compound, allowing for consistent production and research applications

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